Brazil reported earlier on Friday the first monkeypox-related death outside the African continent in the current wave of the disease.
According to a World Health Organization report from July 22, only five deaths had been reported worldwide, all in the African region.
The WHO last Saturday declared the rapidly spreading outbreak a global health emergency, its highest level of alert.
In its latest report, the Spanish Health Ministry said 4,298 cases had been confirmed in the country. Of the 3,750 patients it had information on, it said 120 had been hospitalised and one had died, without providing further details.
A spokesperson for the Health Ministry declined to give further details on the deceased person.